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. 2021 Jun 24;11:704722. doi: 10.3389/fonc.2021.704722

Table 2.

Characteristics and outcome of BRONJ patients.

  BRONJ Patients N = 14 (%)
Predisposing factors  
○ Spontaneous 9
○ Dental Extraction 5
MM status at BRONJ onset  
○ CR 5
○ PR 4
○ PD 5
MM Therapy at BRONJ onset  
○ Lenalidomide 8
○ Carfilzomib 3
○ Other 3
○ Zoledronic acid
▪ Monthly 9
▪ 3 months 5
Symptoms  
○ Mild (exam finding) 10
○ Severe pain, swelling 4
AAOMS staging  
○ 1 1
○ 2 11
○ 3 2
Location of the lesions  
○ Mandible 11
○ Maxilla 1
○ Both 2
BRONJ Outcome  
○ Healed 9
○ Non-healing 5
○ Healed and recurred 3

BRONJ, bisphosphonate related osteonecrosis of the jaw; AAOMS, American Association of Oral and Maxillofacial Surgeons.