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. 2021 Jun 24;12:666047. doi: 10.3389/fphar.2021.666047

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Copyright © 2021 Huang, Liu, Ciotkowska, Tamalunas, Waidelich, Strittmatter, Stief and Hennenberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of mirabegron on EFS-induced contractions of human prostate tissues. Contractions of prostate tissues from the periurethral zone were induced by EFS in an organ bath, 30 min after addition of mirabegron in concentrations of 10 µM (A), 5 µM (B) or 1 µM (C), or an equivalent amount of DMSO (controls), which was used as solvent for mirabegron. Shown are data from n = 5 patients in each diagram, which are means ± SD in frequency response curves (#p < 0.05 for control vs. mirabegron by two-way ANOVA, and p values for whole groups in inserts from 1-way ANOVA).