TABLE 1.

Mean differences (MD) for EFS-induced contractions of human prostate tissues after application of mirabegron (1, 5, 10 µM) or DMSO for controls, shown for each applied frequence and with 95% confidence intervals (CI) (in square brackets, low to high) (% of KCl-induced contractions). Differences in contraction at given frequencies were calculated for each single experiment (i. e., between mirabegron and control group, for corresponding, paired samples from the same prostate in each single experiment), and are expressed as MD with 95% CI.

Mirabegron (µM)	EFS, frequence
	2 Hz	4 Hz	8 Hz	16 Hz	32 Hz
1	−3.8 [−13.2 to 5.5]	−5.1 [−19.0 to 8.8]	−1.9 [−11.2 to 7.4]	−4.1 [−23.6 to 15.5]	3.6 [−22.1 to 29.2]
5	−3.8 [−10.6 to 3.1]	−4.7 [−13.1 to 3.6]	−6.9 [−14.5 to 0.6]	−18.6 [−39.4 to 2.1]	−30.5 [−52.1 to −9.0]
10	-2.7 [-5.1 to -0.2]	−5.1 [−11.7 to 1.4]	−9.5 [−16.6 to -2.3]	−33.3 [−53.3 to −13.4]	−70.3 [−128 to −12.7]

Data are based on experiments on series with n = 5 prostates for each mirabegron concentration and corresponding controls, i. e. 15 prostates in total.