TABLE 5.

Mean differences (MD) for noradrenaline-induced contractions of human prostate tissues after application of either L-748,337, l-NAME, or BPIPP both to control and mirabegron groups, followed by application of mirabegron (10 µM) or DMSO for controls, shown for each applied agonist concentration and with 95% confidence intervals (CI) (in square brackets, low to high) (% of KCl-induced contractions). Differences in contraction at given agonist concentrations were calculated for each single experiment (i. e., between mirabegron and control group, for corresponding, paired samples from the same prostate in each single experiment), and are expressed as MD with 95% CI. Data are based on experiments on series with n = 5 prostates for each mirabegron concentration and corresponding controls with L-748,337 and l-NAME and n = 9 prostates with BPIPP, i. e. 19 prostates in total.

	Noradrenaline concentration
	0.1 µM	0.3 µM	1 µM	3 µM	10 µM	30 µM	100 µM
L-748,337	−1 [−2.1 to 0]	−10.7 [−21.1 to −0.2]	−21.4 [−41.8 to −1]	−43.5 [−109.7 to 22.8]	−29.9 [−81.9 to 22.1]	9.8 [−29.4 to 48.9]	13.2 [−35.7 to 62.1]
l -NAME	−5.5 [−11.9 to 0.8]	−18.6 [−30 to −7.3]	−32.3 [−52.4 to −12.1]	−78.4 [−136 to −20.9]	−74.5 [−130 to −18.6]	−20 [−88.8 to 48.8]	−11.6 [−80.9 to 57.7]
BPIPP	−5.5 [−11.6 to 0.7]	−16.6 [−34.9 to 1.7]	−21.1 [−42.2 to 0]	−20.8 [−52.4 to 10.7]	−22.2 [−57 to 12.6]	−11.4 [−47.8 to 24.9]	−3.7 [−33.4 to 26]