Figure 3.

Protein and transcript abundance of epithelial and stromal markers in HGSOC as well as cellular admixture analyses (xCell (Aran et al., 2017))

(A) Heatmaps depicting protein and transcript abundances and cellular admixture enrichment scores from 343WM for replicate tumor cores and by depth within the specimen block for LMD-enriched tumor, stroma, and whole tumor collections. Protein abundance from the cryopulverized tumor is included. Size and color of each shape reflects Spearman correlation. (B) Boxplots depicting relative protein abundances for KRT19, CDH1, FAP, and VCAN and (C) cellular admixture scores in the n = 9 patient specimen set. ES = LMD-enriched stroma; ET = LMD-enriched tumor; WT = whole tumor. p values with (∗) indicate statistically significant differential expression (p < 0.0001) between ES and ET.