Figure 6.
Patient-specific dendrograms depicting Spearman correlations between LMD-enriched collections based on differentially expressed proteins
(A) Representative relatedness of all collection types from 343WM, including tumor cores, LMD-enriched tumor epithelium, LMD-enriched stroma, whole tumor, and cryopulverized tissue. (B) Relatedness of tumor cores versus LMD-enriched tumor epithelium from 343WM. (C-F) Relatedness of LMD-enriched tumor versus stroma from 343WM, 343WK, 343WQ, and 343WH, respectively. With the exception of the LMD-enriched tumor cores vs LMD-enriched tumor epithelium comparison in (B) which was calculated using proteins with a median absolute deviation (MAD) > 0.5, all comparisons in (A) and (C-F) were made using proteins with MAD >1. Comparisons marked with (∗) indicate a significant difference (p < 0.01) between groups, with p values of 1.264 × 10−5, 0.0012, 0.0003372, 0.00097, and 0.2205 for the comparisons in (B-F), respectively. The yellow, blue, and red ovals in (B-F) highlight the clusters of LMD-enriched tumor cores, tumor epithelium, and stroma, respectively.