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. 2021 Jul 6;41(7):BSR20210326. doi: 10.1042/BSR20210326

Table 4. Analysis of association between CAMKK1 rs7214723 and risk of AS, through an unconditional logistic regression analysis adjusted for sex, age, diabetes, hypertension, BMI and previous history of neoplasia.

rs7214723 AS no. (%) NOAS no. (%) OR (95% CI) Robust Std. Err. P> |Z|
Additive model
Genotype
TT 16 (15%) 17 (8.8%) 1.000 (reference)
TC 71 (66.4%) 122 (63.2%) 0.668 (0.303–1.475) 0.270 0.319
CC 20 (18.6%) 54 (28%) 0.466 (0.185–1.177 0.220 0.107
Age
<60 10 (9.3%) 42 (21.8%) 0.518 (0.223–1.204) 0.222 0.127
≥60 97 (90.7%) 151 (78.2%) 1.000 (reference)
Sex
M 56 (52.3%) 136 (70.5%) 0.445 (0.256–0.774) 0.125 0.004
F 51 (47.7%) 57 (29.5%) 1.000 (reference)
Hypertension
YES 88 (82.2%) 140 (73.3%) 1.297 (0.657–2.559) 0.449 0.453
NO 19 17.8%) 51 (26.7%) 1.000 (reference)
Diabetes
YES 23 (21.5%) 44 (23%) 0.789 (0.411–1.513) 0.262 0.476
NO 84 (78.5%) 147 (77%) 1.000 (reference)
Pre. neoplasia
YES 15 (14%) 14 (7.3%) 1.780 (0.704–4.499) 0.842 0.223
NO 92 (86%) 177 (92.7%) 1.000 (reference)
BMI
≥25% 52 (53.6%) 112 (62.2%) 1.183 (0.682–2.053) 0.332 0.549
<25% 45 (46.4%) 68 (37.8%) 1.000 (reference)
Recessive model
Genotype
TT+TC 87 (81.3%) 139 (72%) 1.000 (reference)
CC 20 (18.7%) 54 (28%) 0.657 (0.349–1.236) 0.211 0.193
Age
<60 10 (9.3%) 42 (21.8%) 0.500 (0.215–1.159) 0.214 0.106
≥60 97 (90.7%) 151 (78.2%) 1.000 (reference)
Sex
M 56 (52.3%) 136 (70.5%) 0.433 (0.250–0.752) 0.121 0.003
F 51 (47.7%) 57 (29.5%) 1.000 (reference)
Hypertension
YES 88 (82.2%) 140 (73.3%) 1.299 (0.655–2.575) 0.453 0.453
NO 19 17.8%) 51 (26.7%) 1.000 (reference)
Diabetes
YES 23 (21.5%) 44 (23%) 0.823 (0.435–1.557) 0.267 0.550
NO 84 (78.5%) 147 (77%) 1.000 (reference)
Pre. neoplasia
YES 15 (14%) 14 (7.3%) 1.797 (0.705–4.580) 0.857 0.219
NO 92 (86%) 177 (92.7%) 1.000 (reference)
BMI
≥25% 52 (53.6%) 112 (62.2%) 1.193 (0.687–2.069) 0.335 0.530
<25% 45 (46.4%) 68 (37.8%) 1.000 (reference)
Dominant model
Genotype
TT 16 (15%) 17 (8.8%) 0.613 (0.282–1.334) 0.243 0.218
CC+TC 91 (85%) 176 (91.1%) 1.000 (reference)
Age
< 60 10 (9.3%) 42 (21.8%) 0.509 (0.219–1.184) 0.218 0.117
≥ 60 97 (90.7%) 151 (78.2%) 1.000 (reference)
Sex
M 56 (52.3%) 136 (70.5%) 0.445 (0.258–0.769) 0.124 0.004
F 51 (47.7%) 57 (29.5%) 1.000 (reference)
Hypertension
YES 88 (82.2%) 140 (73.3%) 1.291 (0.657–2.535) 0.444 0.458
NO 19 17.8%) 51 (26.7%) 1.000 (reference)
Diabetes
YES 23 (21.5%) 44 (23%) 0.803 (0.421–1.533) 0.264 0.508
NO 84 (78.5%) 147 (77%) 1.000 (reference)
Pre. neoplasia
YES 15 (14%) 14 (7.3%) 1.718 (0.694–4.253) 0.794 0.242
NO 92 (86%) 177 (92.7%) 1.000 (reference)
BMI
≥25% 52 (53.6%) 112 (62.2%) 1.186 (0.684–2.056) 0.332 0.541
<25% 45 (46.4%) 68 (37.8%) 1.000 (reference)

Abbreviations: Prev. neoplasia, previous history of neoplasia; P> |Z|, P-value from Z score; Robust Std. Err., robust standard error.

Additive model

Log pseudolikelihood = −162.35768

Prob > χ2 = 0.0177

Recessive model

Log pseudolikelihood = −162.83012

Prob > χ2 = 0.0112

Dominant model

Log pseudolikelihood = −162.95108

Prob > χ2 = 0.0171