Table 4. Analysis of association between CAMKK1 rs7214723 and risk of AS, through an unconditional logistic regression analysis adjusted for sex, age, diabetes, hypertension, BMI and previous history of neoplasia.
rs7214723 | AS no. (%) | NOAS no. (%) | OR (95% CI) | Robust Std. Err. | P> |Z| |
---|---|---|---|---|---|
Additive model | |||||
Genotype | |||||
TT | 16 (15%) | 17 (8.8%) | 1.000 (reference) | ||
TC | 71 (66.4%) | 122 (63.2%) | 0.668 (0.303–1.475) | 0.270 | 0.319 |
CC | 20 (18.6%) | 54 (28%) | 0.466 (0.185–1.177 | 0.220 | 0.107 |
Age | |||||
<60 | 10 (9.3%) | 42 (21.8%) | 0.518 (0.223–1.204) | 0.222 | 0.127 |
≥60 | 97 (90.7%) | 151 (78.2%) | 1.000 (reference) | ||
Sex | |||||
M | 56 (52.3%) | 136 (70.5%) | 0.445 (0.256–0.774) | 0.125 | 0.004 |
F | 51 (47.7%) | 57 (29.5%) | 1.000 (reference) | ||
Hypertension | |||||
YES | 88 (82.2%) | 140 (73.3%) | 1.297 (0.657–2.559) | 0.449 | 0.453 |
NO | 19 17.8%) | 51 (26.7%) | 1.000 (reference) | ||
Diabetes | |||||
YES | 23 (21.5%) | 44 (23%) | 0.789 (0.411–1.513) | 0.262 | 0.476 |
NO | 84 (78.5%) | 147 (77%) | 1.000 (reference) | ||
Pre. neoplasia | |||||
YES | 15 (14%) | 14 (7.3%) | 1.780 (0.704–4.499) | 0.842 | 0.223 |
NO | 92 (86%) | 177 (92.7%) | 1.000 (reference) | ||
BMI | |||||
≥25% | 52 (53.6%) | 112 (62.2%) | 1.183 (0.682–2.053) | 0.332 | 0.549 |
<25% | 45 (46.4%) | 68 (37.8%) | 1.000 (reference) | ||
Recessive model | |||||
Genotype | |||||
TT+TC | 87 (81.3%) | 139 (72%) | 1.000 (reference) | ||
CC | 20 (18.7%) | 54 (28%) | 0.657 (0.349–1.236) | 0.211 | 0.193 |
Age | |||||
<60 | 10 (9.3%) | 42 (21.8%) | 0.500 (0.215–1.159) | 0.214 | 0.106 |
≥60 | 97 (90.7%) | 151 (78.2%) | 1.000 (reference) | ||
Sex | |||||
M | 56 (52.3%) | 136 (70.5%) | 0.433 (0.250–0.752) | 0.121 | 0.003 |
F | 51 (47.7%) | 57 (29.5%) | 1.000 (reference) | ||
Hypertension | |||||
YES | 88 (82.2%) | 140 (73.3%) | 1.299 (0.655–2.575) | 0.453 | 0.453 |
NO | 19 17.8%) | 51 (26.7%) | 1.000 (reference) | ||
Diabetes | |||||
YES | 23 (21.5%) | 44 (23%) | 0.823 (0.435–1.557) | 0.267 | 0.550 |
NO | 84 (78.5%) | 147 (77%) | 1.000 (reference) | ||
Pre. neoplasia | |||||
YES | 15 (14%) | 14 (7.3%) | 1.797 (0.705–4.580) | 0.857 | 0.219 |
NO | 92 (86%) | 177 (92.7%) | 1.000 (reference) | ||
BMI | |||||
≥25% | 52 (53.6%) | 112 (62.2%) | 1.193 (0.687–2.069) | 0.335 | 0.530 |
<25% | 45 (46.4%) | 68 (37.8%) | 1.000 (reference) | ||
Dominant model | |||||
Genotype | |||||
TT | 16 (15%) | 17 (8.8%) | 0.613 (0.282–1.334) | 0.243 | 0.218 |
CC+TC | 91 (85%) | 176 (91.1%) | 1.000 (reference) | ||
Age | |||||
< 60 | 10 (9.3%) | 42 (21.8%) | 0.509 (0.219–1.184) | 0.218 | 0.117 |
≥ 60 | 97 (90.7%) | 151 (78.2%) | 1.000 (reference) | ||
Sex | |||||
M | 56 (52.3%) | 136 (70.5%) | 0.445 (0.258–0.769) | 0.124 | 0.004 |
F | 51 (47.7%) | 57 (29.5%) | 1.000 (reference) | ||
Hypertension | |||||
YES | 88 (82.2%) | 140 (73.3%) | 1.291 (0.657–2.535) | 0.444 | 0.458 |
NO | 19 17.8%) | 51 (26.7%) | 1.000 (reference) | ||
Diabetes | |||||
YES | 23 (21.5%) | 44 (23%) | 0.803 (0.421–1.533) | 0.264 | 0.508 |
NO | 84 (78.5%) | 147 (77%) | 1.000 (reference) | ||
Pre. neoplasia | |||||
YES | 15 (14%) | 14 (7.3%) | 1.718 (0.694–4.253) | 0.794 | 0.242 |
NO | 92 (86%) | 177 (92.7%) | 1.000 (reference) | ||
BMI | |||||
≥25% | 52 (53.6%) | 112 (62.2%) | 1.186 (0.684–2.056) | 0.332 | 0.541 |
<25% | 45 (46.4%) | 68 (37.8%) | 1.000 (reference) |
Abbreviations: Prev. neoplasia, previous history of neoplasia; P> |Z|, P-value from Z score; Robust Std. Err., robust standard error.
Additive model
Log pseudolikelihood = −162.35768
Prob > χ2 = 0.0177
Recessive model
Log pseudolikelihood = −162.83012
Prob > χ2 = 0.0112
Dominant model
Log pseudolikelihood = −162.95108
Prob > χ2 = 0.0171