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. 2021 Jun 24;15:690159. doi: 10.3389/fnins.2021.690159

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Copyright © 2021 Hou, Chen, Wang, Liu, Mao, Qu, Shen, Yu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transient vmPFC inactivation disrupts the effects of EA on anxiety-like behaviors in MSPS model rats. (A) A timeline of MSPS modeling, EA treatment, stereotactic injection, and behavioral testing protocols. Briefly, MSPS modeling was performed on day 1. After a 7-day rest, rats were treated once per day as per an EA protocol (days 9–22). On day 23, rats were stereotaxically injected with artificial CSF (aCSF) or a 1.0 nmol/0.1 nmol mixture of baclofen and muscimol (BM) in the bilateral vmPFC immediately prior to behavioral testing. (B) Time spent in the open arms during elevated plus maze (EPM) testing for rats in the indicated groups. (C) Percentage of time spent in open arms. (D–G) Real-time movement traces during EPC testing: (D) BM + MSPS group; (E) BM + MSPS + EA group; (F) EA + MSPS group; (G) EA + BM group. *#P < 0.05 vs. the BM + MSPS group and the BM + MSPS + EA group.