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. 2021 Jun 24;9:649446. doi: 10.3389/fbioe.2021.649446

Figure 1.

Figure 1

Wound healing progress has been evaluated in all subjects included in the study for 16 weeks. The Kaplan–Meier plot shows the dynamics of patients exiting the study and predicts the healing potential of AM over time (A). During the first 4 weeks of the study, wound granulation and epithelization were observed in 43.8% of the patients (N = 7), three of which exited the study due to the complete wound healing. Between weeks 3 and 12 (A), 80% wound size reduction (B) and total healing in 50% of all subjects (N = 8) enrolled to the study (C, D) have been observed. The study shows complete ulcer healing in half of the patients, 37% of the wounds had a significant size reduction (up to 90% of baseline size), and 13% of the ulcers were not responding to the therapy (N = 2). Therapy outcomes, DM group (E): complete healing (40%, N = 4), significant reduction of the ulcer size (40%, N = 4), and unresponsive to the therapy (30%, N = 2). Therapy outcomes, NDM group (F): complete healing (66%, N = 4), significant (up to 83%) reduction of the ulcer size (33%, N = 2), and unresponsive to the therapy (0%). A very significant changes (p < 0.001) are marked as***.