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. 2021 Jun 24;9:649446. doi: 10.3389/fbioe.2021.649446

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Copyright © 2021 Schmiedova, Ozanova, Stastna, Kiselakova, Lipovy and Forostyak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wound healing dynamics after Amnioderm® application: NDM (A), DM (B), and non-responder NDM (C) groups. A female patient (69 years old) suffering from a non-diabetic chronic wound for 12 months (A). After four Amnioderm® applications, a significant reduction of ulcer size was observed, leading to complete healing after 6 weeks. An example of a female patient (58 years old) with a confirmed diagnosis of DM, suffering from a chronic ulcer at the lower limb for 18 months (B). After 4 weeks of Amnioderm® therapy, the wound completely healed by the 10th week. An example of a patient (female, 67 years old) with a history of chronic wound of venous etiology (C). Applications of AM led to a significant reduction of pain and size of a wound, but not complete healing. Scale bars = 1 cm. NDM, non-diabetic patients; DM, diabetes mellitus type II patients.