Fig. 6.

PDT treatment causes ferroptosis-like cell death and tumor regression in A549 bearing mice. a, Tumor growth inhibition by PDT and effect of Lip-1. b-c, Quantification of the GSH level (b) and MDA level (c) in frozen tumor sections obtained at different times after PDT with 4 mg/kg Verteporfin. d, Images of resected tumors obtained 14 days after PDT treatment. e, Changes of mRNA expressions in frozen tumor sections obtained 3 days after PDT treatment. f, Expression of ACSL4 and GPX4 by Western blotting analysis in tumors at different times upon PDT with 4 mg/kg Verteporfin. g, Histological examination of tumors by H&E staining. h, Mechanistic scheme of PDT triggered lipid peroxidation and liperoptosis.