Table 3.
The levels (mean±SEM, n=7) of serum biochemical markers including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), albumin (ALB), total (Total Bil) and direct bilirubin (Direct Bil) in the control, vehicle-treated, acetaminophen-treated (500 mg/kg/day), Milk Thistle Extract treated (MTE 200 and 400 mg/kg/day) and chicory Extract treated (CE500 and 1000 mg/kg/day) groups after 28 days
| AST | ALT | LDH | GGT | ALP | Alb | Total Bil | Direct Bil | |
|---|---|---|---|---|---|---|---|---|
| Control | 104.0±1.51 | 70.0±2.50 | 695.0±76.88 | 2.5±0.64 | 837.6±48 | 3.78±0.07 | 0.20±0.03 | 0.10±0.00 |
| Vehicle | 110.3±3.60 | 73.16±2.15 | 759.8±39.88 | 3.7±0.54 | 767.5±32.2 | 3.68±0.08 | 0.20±0.00 | 0.13±0.01 |
| Acet. | 169.0±15.67** | 148.2±13.76* | 1119.4±136.8** | 2.71±0.96 | 850.0±56.52 | 3.64±0.06 | 0.25±0.02 | 0.11±0.01 |
| MTE200 | 104.5±6.6†† | 65.7±6.0††† | 898.0±58.3* | 2.5±0.5 | 636.3±45††* | 3.65±0.11 | 0.22±0.03 | 0.10±0.01 |
| MTE400 | 118.0±6.5†† | 72.5±5.5††† | 787.5±47.8† | 3.5±0.95 | 640.2±43.3††* | 3.68±0.05 | 0.24±0.02 | 0.11±0.03 |
| CE500 | 92.2±2.5††† | 63.5±7.1††† | 733.6±43.8†† | 2.2±0.47 | 616.1±46.4**†† | 3.80±0.05 | 0.22±0.02 | 0.12±0.02 |
| CE1000 | 98.8±3.9†† | 65.0±2.00††† | 594.2±41.6††● | 3.0±0.22 | 803.5±23.7● | 3.82±0.05 | 0.21±0.03 | 0.10±.02 |
*Significant difference compared tothe control group (*p<0.05 and**p<0.01); †significant difference compared tothe acetaminophen-treated group (†p<0.05, ††p<0.01 and †††p<0.001); ●significant difference compared to the CE500-treated group (●p<0.05)