Table 1.
Comparison of clinical characteristics between patients with and without alcoholic liver cirrhosis
| Variable | Alcoholic LC | Non‐alcoholic LC | P value |
|---|---|---|---|
| Patients, n (%) | 64 (35.4) | 117 (64.6) | |
| Man, n (%) | 49 (76.6) | 68 (58.1) | 0.013 |
| Age (years) | 61.5 (50.5–70.0) | 72.0 (63.5–78.0) | <0.001 |
| BMI (kg/m2) | 22.8 (21.2–25.5) | 23.8 (21.1–26.3) | 0.255 |
| Child–Pugh B + C, n (%) | 27 (42.2) | 29 (24.8) | 0.015 |
| HBV/HCV/PBC/Other, n | 17/56/11/33 | ||
| Total bilirubin (mg/dL) | 1.0 (0.7–1.4) | 0.8 (0.6–1.2) | 0.017 |
| Albumin (g/dL) | 3.8 (3.4–4.2) | 3.9 (3.5–4.3) | 0.457 |
| Prothrombin time (%) | 74 (62–85) | 86 (72–98) | <0.001 |
| M2BPGi (C.O.I) | 3.16 (1.46–6.82) | 2.88 (1.54–5.87) | 0.582 |
| BCAA (μmol/L) | 394 (320–449) | 401 (327–486) | 0.210 |
| IGF‐1 (ng/mL) | 55 (41–77) | 55 (43–72) | 0.604 |
| 25(OH)D (ng/mL) | 11.5 (9.0–16.2) | 13.3 (9.7–17.4) | 0.265 |
| Zinc (μg/dL) | 65 (54–71) | 65 (54–75) | 0.719 |
| SMI (kg/m2) | |||
| All patients | 7.32 (6.43–8.11) | 6.67 (5.76–7.72) | 0.004 |
| Man | 7.43 (6.97–8.35) | 7.18 (6.62–8.23) | 0.414 |
| Woman | 6.33 (5.75–6.58) | 5.76 (5.03–6.21) | 0.014 |
| Handgrip strength (kg) | |||
| All patients | 30.1 (23.6–36.9) | 23.5 (16.6–33.4) | 0.001 |
| Man | 34.0 (28.1–38.8) | 32.0 (24.3–38.0) | 0.327 |
| Woman | 21.5 (16.5–24.6) | 16.4 (14.1–21.1) | 0.006 |
| Sarcopenia, n (%) | 12 (18.8) | 38 (32.5) | 0.048 |
| Gait speed (m/s) | 1.10 (1.00–1.33) | 1.03 (0.79–1.19) | 0.006 |
| Slow gait speed, n (%) | 14 (21.9) | 56 (47.9) | 0.001 |
Values are presented as median (interquartile range) or number (percentage). Statistical analysis was performed using the chi‐squared test or the Mann–Whitney U test, as appropriate.
25(OH)D, 25‐hydroxyvitamin D; BCAA, branched‐chain amino acid; BMI, body mass index; HBV, hepatitis B virus; HCV, hepatitis C virus; IGF‐1, insulin‐like growth factor 1; LC, liver cirrhosis; M2BPGi, Mac‐2 binding protein glycosylation isomer; PBC, primary biliary cholangitis; SMI, skeletal muscle mass index.