Table 2.
Comparison of clinical characteristics between patients with and without sarcopenia in patients with alcoholic liver cirrhosis
| Variable | Sarcopenia | Non‐sarcopenia | P value |
|---|---|---|---|
| Patients, n (%) | 12 (18.8) | 52 (81.3) | |
| Man, n (%) | 10 (83.3) | 39 (75.0) | 0.539 |
| Age (years) | 73.5 (59.0–75.0) | 59.0 (50.0–68.0) | 0.020 |
| BMI (kg/m2) | 21.9 (18.8–22.3) | 23.6 (21.5–26.2) | 0.006 |
| Cumulative alcohol consumption (kg) | 1095 (908–1256) | 1026 (770–1311) | 0.667 |
| Current drinking, n (%) | 7 (58.3) | 27 (51.9) | 0.688 |
| Child–Pugh B + C, n (%) | 5 (41.7) | 22 (42.3) | 0.968 |
| Total bilirubin (mg/dL) | 1.0 (0.7–1.7) | 1.0 (0.7–1.4) | 0.829 |
| Albumin (g/dL) | 3.5 (3.4–4.0) | 3.9 (3.4–4.3) | 0.215 |
| Prothrombin time (%) | 76 (66–91) | 74 (62–85) | 0.486 |
| M2BPGi (C.O.I) | 2.68 (1.95–8.17) | 3.39 (1.39–6.73) | 0.730 |
| BCAA (μmol/L) | 336 (231–350) | 407 (336–478) | 0.006 |
| IGF‐1 (ng/mL) | 49 (34–63) | 59 (41–82) | 0.156 |
| 25(OH)D (ng/mL) | 10.1 (9.1–17.0) | 11.9 (8.9–16.2) | 0.919 |
| Zinc (μg/dL) | 58 (47–69) | 65 (58–73) | 0.146 |
| SMI (kg/m2) | 6.14 (5.56–6.95) | 7.42 (6.91–8.32) | <0.001 |
| Handgrip strength (kg) | 20.0 (16.4–25.0) | 32.8 (28.2–38.4) | <0.001 |
| Gait speed (m/s) | 0.84 (0.62–1.04) | 1.23 (1.03–1.35) | <0.001 |
| Slow gait speed, n (%) | 9 (75.0) | 5 (9.6) | <0.001 |
Values are presented as median (interquartile range) or number (percentage). Statistical analysis was performed using the chi‐squared test or the Mann–Whitney U test, as appropriate.
25(OH)D, 25‐hydroxyvitamin D; BCAA, branched‐chain amino acid; BMI, body mass index; IGF‐1, insulin‐like growth factor 1; M2BPGi, Mac‐2 binding protein glycosylation isomer; SMI, skeletal muscle mass index.