Table 1.
Number and prevalence of neural tube defect (NTD) pregnancies in EUROCAT registries reported from 1998 to 2017 and the proportion of the population covered over the whole 20 year period.
| Country | EU member | Registry | First year | Last year | Total number of NTD pregnancies* | Prevalence of NTD pregnancies per 1,000 births | Coverage of all 20 years national births data available† (%) | |
|---|---|---|---|---|---|---|---|---|
| 2017 | 1998 | |||||||
| Belgium | Y | Y | Antwerp | 1998 | 2016 | 271 | 0.73 | 15 |
| Belgium | Y | Y | Hainaut | 1998 | 2017 | 194 | 0.79 | 10 |
| Denmark | Y | Y | Odense | 1998 | 2015 | 105 | 1.14 | 7 |
| France | Y | Y | Auvergne | 2002 | 2015 | 170 | 1.05 | 1 |
| France | Y | Y | Brittany | 2011 | 2017 | 321 | 1.31 | 2 |
| France | Y | Y | Paris | 1998 | 2017 | 634 | 1.13 | 3 |
| Italy | Y | Y | Emilia Romagna | 1998 | 2017 | 391 | 0.57 | 6 |
| Italy | Y | Y | Tuscany | 1998 | 2017 | 317 | 0.56 | 5 |
| Ireland | Y | Y | Cork and Kerry | 1998 | 2017 | 210 | 1.16 | 14 |
| Ireland | Y | Y | Dublin | 1998 | 2012 | 255 | 0.70 | 28 |
| Ireland | Y | Y | SE Ireland | 1998 | 2016 | 137 | 1.05 | 10 |
| Netherlands | Y | Y | North Netherlands | 1998 | 2017 | 291 | 0.81 | 10 |
| UK | Y | Y | East Midlands and South Yorkshire | 1998 | 2017 | 1,288 | 1.13 | 8 |
| UK | Y | Y | Northern England | 2000 | 2017 | 775 | 1.35 | 4 |
| UK | Y | Y | South West England | 2005 | 2017 | 717 | 1.12 | 4 |
| UK | Y | Y | Thames Valley | 1998 | 2017 | 448 | 1.04 | 3 |
| UK | Y | Y | Wales | 1998 | 2017 | 942 | 1.41 | 4 |
| UK | Y | Y | Wessex | 1998 | 2017 | 684 | 1.20 | 4 |
| Portugal | Y | Y | S. Portugal | 1998 | 2017 | 156 | 0.43 | 18 |
| Spain‡ | Y | Y | Basque | 1998 | 2016 | 374 | 1.02 | 4 |
| Spain‡ | Y | Y | Valencian Region | 2007 | 2016 | 293 | 0.60 | 6 |
| Germany | Y | Y | Mainz | 1998 | 2014 | 89 | 1.63 | 0 |
| Germany | Y | Y | Saxony-Anhalt | 1998 | 2017 | 308 | 0.92 | 2 |
| Austria | Y | Y | Styria | 1998 | 2014 | 129 | 0.73 | 11 |
| Finland | Y | Y | Finland (A) | 1998 | 2014 | 899 | 0.91 | 86 |
| Sweden | Y | Y | Sweden (A) | 2007 | 2016 | 803 | 0.73 | 53 |
| Croatia | Y | N | Zagreb | 1998 | 2017 | 60 | 0.49 | 15 |
| Malta | Y | N | Malta | 1998 | 2016 | 73 | 0.92 | 96 |
| Poland | Y | N | Wielkopolska | 1999 | 2017 | 517 | 0.73 | 9 |
| Bulgaria | Y | N | Sofia (A) | 1998 | 1999 | 40 | 2.07 | 1 |
| Hungary | Y | N | Hungary (A) | 1998 | 2012 | 953 | 0.66 | 76 |
| Czech Rep | Y | N | Czech Republic (A) | 2000 | 2010 | 848 | 0.74 | 55 |
| Switzerland | N | N | Vaud | 1998 | 2017 | 135 | 0.87 | 10 |
| Norway | N | N | Norway | 1999 | 2016 | 907 | 0.84 | 92 |
| Ukraine | N | N | Ukraine | 2005 | 2016 | 650 | 1.80 | 4 |
Associate registry.
Includes NTDs occurring in live births, fetal deaths (stillbirths and later miscarriages ≥ 20 gestational age) and terminations of pregnancy for fetal anomaly excluding cases with known genetic conditions.
This figure is the total number of births covered by the registry in the years reported divided by the total numbers of births occurring in the countries over the whole 20-year period.
The prevalence is confirmed by the data from hospitals recording terminations of pregnancy for fetal anomalies in the Spanish Collaborative Study of Congenital Malformations (ECEMC)—an associate registry in EUROCAT which covers 16% of all births and includes hospitals from Valencian and Basque regions (19).