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. 2021 Jun 24;11:682968. doi: 10.3389/fonc.2021.682968

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Copyright © 2021 De Grandis, Oliveira, Guedes, dos Santos, Aissa, Batista and Pavan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction of ruthenium-containing ruthenium complexes with DNA molecule. (A) Emission spectra of Hoechst (HO) (2.7 µM, λ_ex = 343 nm), CT-DNA (125 µM) in presence of the complex (2) in different concentrations (0 - 125 µM). (B) Agarose gel electrophoresis image of pBR322 plasmid DNA incubated with complexes (1) and (2). The pBR322 presents three forms, OC (open circular), L (linear) and SC (supercoiled). Lane 1 (M): molecular weight marker; lane 2 (DNA): pure pBR322 with DMSO; lanes 3–6 [complex (1)] and lanes 7-10 [complex (2)].