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. 2021 Jun 24;11:655781. doi: 10.3389/fonc.2021.655781

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Copyright © 2021 Moradi Kashkooli, Soltani, Momeni and Rahmim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of drug delivery mechanisms considered in the current study. (A) one-stage DDS or conventional chemotherapeutic delivery, (B) two-stage DDS (i.e., NP delivery), and (C) three-stage DDS.