Table 1.
Drug-target networks were retrieved using the “Gene Association” module of NDEx v2.4.5.
| Network Name | Query result | |
|---|---|---|
| Network Properties | Number of overlapping gene | |
| DrugBank - Combined Network Parent: Nodes:11994; Egde:27799 | Nodes:106; Egde:119 | 14 genes |
| DisGeNET - Gene-Disease Associations (Score >=0.5) Parent: Nodes:8631; Egde:8273 | Nodes:75; Egde:79 | 14 genes |
| DrugBank - Target drugs Parent: Nodes:11407; Egde:19650 | Nodes:104; Egde:118 | 13 genes |
| BioGRID: Protein-Chemical Interactions (H. sapiens) Parent: Nodes:6776; Egde:10854 | Nodes: 52; Egde:45 | 12 genes |
| BindingDB - High Affinity Compounds vs. human targets (Commercially available) Parent: Nodes:1374; Egde:3371 | Nodes: 7; Egde:6 | 2 genes |
| DrugBank - Enzyme drugs Parent: Nodes:1984; Egde:4905 | Nodes: 2; Egde:1 | 1 gene |
The “host response signature network” was used as a query to find the potential drug molecules.