Table 4. Univariate and multivariable Cox regression analysis of potential risk factors associated with relapse-free survival in part-solid nodules (n=372).
| Factor | RFS | ||||
|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Sex, female | 1.742 (0.654–4.640) | 0.267 | |||
| Age | 1.005 (0.968–1.043) | 0.794 | |||
| Smoking status | 1.991 (0.683–5.800) | 0.207 | |||
| ASA score | |||||
| 1 | 1 | – | |||
| 2 | 1.048 (0.462–2.374) | 0.911 | |||
| 3 | 1.639 (0.363–7.397) | 0.520 | |||
| BMI, kg/m2 | 0.962 (0.840–1.100) | 0.569 | |||
| FEV1% predicted | 0.999 (0.970–1.027) | 0.921 | |||
| Total lesion size, mm | |||||
| (0, 10] | 1 | – | – | ||
| (10, 20] | 2.380 (0.298–19.027) | 0.414 | 0.826 | ||
| (20, 30] | 7.322 (0.971–55.217) | 0.053 | 0.784 | ||
| Solid component size, mm | |||||
| (0, 10] | 1 | – | 1 | – | |
| (10,20] | 6.992 (2.337–20.920) | 0.001 | 4.577 (1.457–14.382) | 0.009 | |
| (20,30] | 18.538 (4.967–69.184) | <0.001 | 6.351 (1.515–26.628) | 0.011 | |
| CTR, % | 1.041 (1.021–1.062) | <0.001 | 0.753 | ||
| Surgery, | |||||
| Sublobar resections | 1 | – | – | ||
| Lobectomy | 1.732 (0.692–4.337) | 0.241 | 0.624 | ||
| SND | 2.286 (0.955–5.473) | 0.063 | 0.940 | ||
| LVI | 21.739 (8.058–58.647) | <0.001 | 4.266 (1.367–13.312) | 0.012 | |
| VPI | 4.131 (1.417–12.046) | 0.009 | 0.422 | ||
| M/S component | 8.974 (4.022–20.021) | <0.001 | 0.384 | ||
| Pathological N1/N2 | 20.554 (9.180–46.023) | <0.001 | 7.401 (2.847–19.237) | <0.001 | |
RFS, relapse-free survival; HR, hazard ratio; CI, confidence interval; ASA, American Society of Anesthesiologists; BMI, body mass index; FEV1, forced expiratory volume in 1 second; CTR, consolidation-to-tumor ratio; SND, systematic lymph node dissection; LVI, lymphovascular invasion; VPI, visceral pleural invasion; M/S component, histological micropapillary or solid component.