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. 2021 Jun;10(6):2830–2841. doi: 10.21037/tlcr-20-788

Table 2. Breg phenotypes in human NSCLC.

Study N Phenotype Mechanism of immunosuppression
Zhou et al., 2014 (55) 268 CD19+CD24hiCD27+ IL-10
Lizotte et al., 2016 (59) 51 CD19+CD24hiCD38hiCD5+CD1dhiCD27+ IL-10
Zhang et al., 2016 (60) 9 CD19+CD5+ STAT3 via IL-10
Bruno et al., 2017 (40) 62 CD19+CD20+CD69+CD27CD21 Treg cells via IL-10 and TGF-β
Ma et al., 2020 (61) 20 CD19+CD24hiCD38hi IL-10

Breg, B regulatory cell; NSCLC, non-small cell lung cancer; Treg, T regulatory cell.