Table 2. Breg phenotypes in human NSCLC.
Study | N | Phenotype | Mechanism of immunosuppression |
---|---|---|---|
Zhou et al., 2014 (55) | 268 | CD19+CD24hiCD27+ | IL-10 |
Lizotte et al., 2016 (59) | 51 | CD19+CD24hiCD38hiCD5+CD1dhiCD27+ | IL-10 |
Zhang et al., 2016 (60) | 9 | CD19+CD5+ | STAT3 via IL-10 |
Bruno et al., 2017 (40) | 62 | CD19+CD20+CD69+CD27–CD21– | Treg cells via IL-10 and TGF-β |
Ma et al., 2020 (61) | 20 | CD19+CD24hiCD38hi | IL-10 |
Breg, B regulatory cell; NSCLC, non-small cell lung cancer; Treg, T regulatory cell.