Table 3.

Association between epitopic specificity of ACPAs and HLA-DRB1 alleles.

		Shared Epitope				HLA-DRB1*04:01				HLADRB1*04:04,*04:05,				HLADRB1*10:01
		N=104/155				N=44/155				*04:08,*01 N=69/155				N=14/155
		NO	YES	Odds Ratio	p	NO	YES	Odds Ratio	p	NO	YES	Odds Ratio	p	NO	YES	Odds Ratio	p
		(n)	(n)	[CI 95%]		(n)	(n)	[CI 95%]		(n)	(n)	[CI 95%]		(n)	(n)	[CI 95%]
β60-74cit	NO (n)	25	40	1.54	0.21	49	16	1.38	0.37	37	28	1.11	0.76	61	4	1.91	0.29
				[0.80 – 2.98]				[0.68 – 2.84]				[0.58 – 2.13]				[0.60 – 5.72]
	YES (n)	26	64			62	28			49	41			80	10
α36-50cit	NO (n)	45	88	1.36	0.54	95	38	0.93	0.90	77	56	1.99	0.14	120	13	0.44	0.42
				[0.54 – 3.68]				[0.34 – 2.41]				[0.804 – 4.69]				[0.04 – 2.68]
	YES (n)	6	16			16	6			9	13			21	1
α621-635cit	NO (n)	23	62	0.55	0.08	55	30	0.46	0.04	45	40	0.80	0.48	79	6	1.70	0.34
				[0.28 – 1.06]				[0.23 – 0.95]				[0.42 – 1.50]				[0.53 – 5.27]
	YES (n)	28	42			56	14			41	29			62	8
α501–515cit	NO (n)	23	28	2.23	0.02	46	5	5.52	0.0003	31	20	1.38	0.35	45	6	0.63	0.40
				[1.10 – 4.55]				[2.00 – 13.64]				[0.71 – 2.77]				[0.19 – 1.97]
	YES (n)	28	76			65	39			55	49			96	8
α171–185cit	NO (n)	15	22	1.55	0.26	30	7	1.96	0.14	22	15	1.24	0.58	35	2	1.65	0.52
				[0.74 – 3.28]				[0.78 – 5.00]				[0.60 – 2.71]				[0.41 – 7.81]
	YES (n)	36	82			81	37			64	54			106	10
Number of specificities	≤3	42	77	1.63	0.25	85	34	0.96	0.92	69	50	1.54	0.25	111	8	2.78	0.07
				[0.71 – 4.01]				[0.42 – 2.20]				[0.74 – 3.28]				[0.85 – 8.31]
	>3	9	27			26	10			17	19			30	6

N, number. Bold values are the significant ones.