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. 2021 Jun 24;14:681868. doi: 10.3389/fnmol.2021.681868

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Copyright © 2021 Molnar-Kasza, Hinteregger, Neddens, Rabl, Flunkert and Hutter-Paier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microgliosis in the spinal cord of 24–30 weeks old SOD1-G93A/low mice. Female and male 24, 27, and 30 weeks old SOD1-G93A/low mice were evaluated for ionized calcium-binding adaptor molecule 1 (Iba1) expression (A–C) in the cervical (A), thoracic (B), and lumbar (C) ventral horn compared to ntg littermates. Two-way ANOVA with Tukey's and Sidak's multiple comparison post hoc test; n = 4 per group. Mean + SEM. */^#p < 0.05, **/^##p < 0.01, ***/^###p < 0.001. *Differences between genotypes; ^#differences between age groups. (D) Representative images of Iba1 labeling in the thoracic spinal cord of 24, 27, and 30 weeks old male SOD1-G93A/low mice compared to ntg littermates.