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. 2021 Jun 24;9:657158. doi: 10.3389/fcell.2021.657158

FIGURE 4.

FIGURE 4

Breast tumor-derived exosomes regulate tumor progression through activation of alveolar epithelial type II cells (AEC II). (A) Isolation of primary lung fibroblasts, AEC II, and pulmonary endothelial cell from mouse lung. (B) mRNA expression of CCL2 in lung fibroblasts, AEC II, and pulmonary endothelial cells treated with PBS or 4T1 derived exosomes. (C) mRNA expression of niche formation associated gene in AEC II treated with PBS or 4T1 derived exosomes. (D) Immunofluorescent analysis of the colocalization of tumor-derived exosome and AEC II. P values were calculated by unpaired Student’s t-test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).