Fig. 5.

Binding mode of DNA-nanothread with CPT. CPT-DNA-NT complex indicating the across bonding of the drug (Cl₂H₆N₂Pt) with the DNA-NT complex (protein complex structure (3LPV) was obtained from Protein Data Bank. (A) CPT 50. CPT1-DG30. CN7 1.992 Å; (B) CPT 50. CPT1-DG31. CN7 2.096 Å; (C) CPT 50. CPT1-DG6. CN7 2.073 Å; (D) CPT 50. CPT1-DG7. CN7 2.108 Å (Source: https://www.rcsb.org/)); Binding mode of CPT (PubChem CID: 5702198) with DNA-NT complex in three different dimensional views by AutoDock Vina software. (PubChem CID: 5702198).