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. 2021 Jun 24;12:698522. doi: 10.3389/fimmu.2021.698522

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Copyright © 2021 Wang and Zuo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TSLP in the pathogenesis of AD and PVs. TSLP causes Th2 inflammation, pruritus, collagen production, and skin thickening in the pathogenesis of AD. TSLP synergy with CD40L to promote DC activation and IL-23 production, resulting in Th17 inflammation in the context of PVs. TSLP also regulates keratinocyte proliferation in the plaque of PVs, leading to epidermal hyperplasia. PVs, psoriasis vulgaris; AD, atopic dermatitis; ILC2, type 2 innate lymphoid cells; Th2 cells, type 2 T helper cells; Th17 cells, type 17 T helper cells; IL, interleukin.