FIGURE 4.

Altered expression profile of mRNAs in the prefrontal cortex of aged mice. (A) Hierarchical clustering analysis of all differentially expressed mRNAs in the prefrontal cortex of CON group and PND group: the red represents a higher fold change, while the blue represents a lower fold change. (B) The volcano plots of all the detected mRNAs in both the CON and PND groups: The vertical line represents to | log₂ (fold change) | > 1 up and down, respectively, and the horizontal line corresponds to a p-value of 0.05 (–log₁₀ scaled). The red points represent the significantly up-regulated mRNAs and the blue points represent the significantly down-regulated mRNAs. The top ten differentially expressed mRNAs were also indicated in this figure.