Figure 4.

Metastatic tumor sites: TLS density and spatial distribution. (A) Densities of extratumoral secondary follicular TLS (left) and BCL6^- germinal centers (GC BCL6^-, right) in distant metastatic lymph node and skin sites. (B) Densities of secondary follicular TLS (left) and BCL6^- germinal centers (right) over intra- and extratumoral compartments in distant metastatic lymph node and skin sites. In all boxplots, lower and upper hinges correspond to the first and third quartiles, center line to the median. Upper and lower whisker extend from the hinge to the largest value no further than 1.5 times the interquartile range. Values outside this range are shown as outliers (black circles). Individual patient values are shown as black dots.