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. 2021 Jun 24;12:680336. doi: 10.3389/fphar.2021.680336

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Copyright © 2021 Jing, Cen, Gao, Wang, Jiang, Jian, Wu, Guo, Luo, Zhang, Wang, Xu, Zhang, Sun and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBN reduces glomerular pathological changes in STZ-induced rats. (A) Representative photomicrographs of H&E staining, PAS staining, and Masson staining in the kidney. Scale bars, 50 μm in H&E and PAS staining, and 20 μm in Masson staining. (B-D) Semi-quantitative analysis of glomerular surface area, glomerulosclerotic index and tubulointerstitial fibrosis index were shown. 30 images of H&E, PAS, and Masson-stained kidney sections were counted for each rat. n = 13 for vehicle-treated DM group and n = 16 for other groups.