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. 2021 Jun 24;12:680336. doi: 10.3389/fphar.2021.680336

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Copyright © 2021 Jing, Cen, Gao, Wang, Jiang, Jian, Wu, Guo, Luo, Zhang, Wang, Xu, Zhang, Sun and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBN upregulated p-AMPK, PGC-1α, Nrf1, Nrf2, HO-1, and TFAM expression in both STZ-induced rats. (A) Representative Western blots illustrating the expression of p-AMPK, total AMPK, PGC-1α, Nrf1, Nrf2, HO-1, and TFAM in the renal cortices of STZ-induced rats. Bar graphs showing mean Western blot of p-AMPK/AMPK (B), PGC-1α/GAPDH (C), Nrf1/GAPDH (D), Nrf2/GAPDH (E), HO-1/GAPDH (F), and TFAM/GAPDH (G) in the renal cortices of STZ-induced rats. Data are means ± SEM of six rats per group. Significance was determined by one-way ANOVA followed by Tukey’s test. *p < 0.05 and **p < 0.01 vs. Ctrl group. ^# p < 0.05 and ^## p < 0.01 vs. vehicle treated-STZ model group.