Table 4. Correlation between preoperative basic patient information and partial pathological response.
Parameters | MPR (N=16) | Non-MPR (N=22) | P value |
---|---|---|---|
Age | |||
Mean ± SD | 64.75 (3.60) | 59.55 (1.40) | 0.019 [1]* |
Gender | |||
Male | 15 | 21 | 1.000 [2] |
Female | 1 | 1 | |
Smoking history | |||
Yes | 7 | 15 | 0.132 [3] |
No | 9 | 7 | |
Drinking history | |||
Yes | 6 | 11 | 0.444 [3] |
No | 10 | 11 | |
BMI | |||
<18.5 | 1 | 2 | 1.000 [2] |
≥18.5 | 15 | 20 | |
Tumour location | |||
Proximal third | 0 | 3 | 0.240 [2] |
Middle third | 11 | 10 | |
Distal third | 5 | 9 | |
Interval from completion of NACI to surgery (weeks) | 4.94(0.98) | 6.27(0.61) | 0.199 [1] |
Neoadjuvant therapy regimens | |||
Cis-platinum + Paclitaxel + Camrelizumab | 4 | 4 | 0.341 [2] |
Carboplatin + Paclitaxel + Camrelizumab | 1 | 3 | |
Cis-platinum + Paclitaxel + Pembrolizumab | 6 | 10 | |
Cis-platinum + Paclitaxel + Sintilimab | 3 | 0 | |
Carboplatin + Paclitaxel + Pembrolizumab | 2 | 3 | |
Paclitaxel + Nedaplatin + Sintilimab | 0 | 2 | |
Chemotherapy course + immunotherapy course | |||
<4 | 2 | 4 | 1.000 [2] |
≥4 | 14 | 18 | |
Immunotherapy regimen | |||
Camrelizumab | 5 | 7 | 0.732 [2] |
Pembrolizumab | 8 | 13 | |
Sintilimab | 3 | 2 | |
Immunotherapy course | |||
<2 | 2 | 3 | 1.000 [2] |
≥2 | 14 | 19 | |
Staging | |||
III | 12 | 19 | 0.425 [2] |
IVA | 4 | 3 |
[1]: P value is calculated by t-test; [2]: P value is calculated by Fisher exact test; [3]: P value is calculated by chi-squared test. Main Pathological Reaction, MPR; P>0.05 NS, *P<0.05.