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. 2021 Jun 24;12:686333. doi: 10.3389/fimmu.2021.686333

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Copyright © 2021 Weitering, Melsen, van Ostaijen-ten Dam, Weemaes, Schilham and van der Burg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Atypical CD45RA^dimCCR7⁺ population in two samples of classic AT patients. (A) CD4 T cells from classic AT1 showing a large atypical population (86%) which is visualized by the red gate on top of the differentiation subset gates. (B) CD8 T cells from classic AT5 showing a large atypical population (76%) which is visualized by the red rectangular gate on top of the differentiation subset gates. (C) Heatmap of marker intensities [Mean Fluorescent Intensities (MFI; MIN (blue) – MAX (red)] of the CD4⁺ atypical population and the differentiation subsets from sample AT1. (D) Similar to C, but for the CD8⁺ atypical population and the differentiation subsets from sample AT5.