TABLE 1.

Proteins or enzymes influenced by ionizing radiation in fatty acids metabolism and ferroptosis.

	Proteins/enzymes	Expression/Level	Radio-resistance	Functions	References
FAs transport
	FAT/CD36	↑	NA	Transport exogenous FAS across plasma membrane	Martius et al., 2014, 2015; Gonnissen et al., 2017
FAs biogenesis
	CTP	↑	↑	Carries citrate from the mitochondria to the cytosol, associates with cancer aggressiveness	Catalina-Rodriguez et al., 2012
	ACLY	↑	↑	Key enzyme of de novo fatty acid synthesis, cleaves cytosolic citrate into acetyl- CoA and oxaloacetate.	Gottgens et al., 2019
	ACC	↑	↑	Converts acetyl-CoA into malonyl- CoA	Koritzinsky, 2015; Gonnissen et al., 2017
	FASN	↑	↑	Catalyzes the final step of FAs de novo synthesis	Chuang et al., 2019; Chen J. et al., 2020
	ACSL4	↑	↓	Catalyzes AA/AdA to generate acyl-CoA	Ye et al., 2020
Ether synthesis
	PEX5	↑	↑	Receptor for PTS1, target of phosphorylation and ubiquitination,	Wang Y. et al., 2020
	PPARα/γ	↑	↑	Acts as lipid sensors to regulate peroxisomal fatty acid β-oxidation and proliferation	Benedetti et al., 2017; Kaur et al., 2019
	PPARδ	↓	NA	Acts as lipid sensors to regulate peroxisomal fatty acid β-oxidation and proliferation	Kan et al., 2015
Fatty acid oxidation
	CTP1	↓	↑	The rate-limiting enzyme of FAO	Zammit et al., 1989; Tan et al., 2018
Redox
	SLC7A11	↓	↓	Transport cystine into cytoplasm	Richards et al., 2009
	GPX4	↓	↓	Major antioxidant enzyme, reduces phospholipid hydroperoxides, inhibits lipid peroxidation	Ye et al., 2020
	GSH	↓	↓	The major cellular thiol participating in cellular redox reactions and thioether formation	Meister and Anderson, 1983; Ye et al., 2020
	GSSG	↓	↓		Meister and Anderson, 1983; Ye et al., 2020
Derivation
	4-HNE	↑	NA	Unfold protein response (upr)	Poli et al., 2008; Zhong and Yin, 2015
	MDA	↑	NA	Modifies and cross-links proteins	Richards et al., 2009

FA, fatty acid; IR, ionizing radiation; CTP, mitochondrial citrate transporter protein; ACLY, ATP citrate lyase; ACC, Acetyl-CoA Carboxylase; FASN, fatty acid synthase; ACSL4, acyl-CoA synthetase long-chain family member 4; PEX, peroxisomal biogenesis factor; PPAR, peroxisome proliferator-activated receptors; FAT/CD36, fatty acid transposase; CTP1, carnitine palmitoyl transferase 1; GPX4, Phospholipid hydroperoxide glutathione peroxidase; GSH Glutathione; GSSG, glutathione disulfide; MDA, malondialdehyde; 4HNE, 4-Hydroxy-2-non-enal.