Table 2.
Univariate and multivariate analysis of the clinical, dosimetric factors and inflammation indexes in predicting grade ≥2 RE.
| Clinicopathologic Parameters | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Gender | ||||||
| Male vs. Female | 0.727 | 0.504-1.051 | 0.090 | 0.717 | 0.474-1.083 | 0.114 |
| Age (years) | ||||||
| ≥65 vs. <65 | 0.944 | 0.670-1.329 | 0.739 | |||
| Weight loss | ||||||
| Yes vs. No | 1.266 | 0.901–1.779 | 0.174 | 1.31 | 0.889-1.929 | 0.172 |
| Tumor location | ||||||
| Cervical/Upper vs. Middle/Lower | 1.188 | 0.835–1.691 | 0.339 | |||
| RT dose (Gy) | ||||||
| >61.5 vs. ≤61.5 | 4.393 | 2.783-6.934 | <0.001 | 4.68 | 2.841-6.709 | <0.001 |
| Chemotherapy | ||||||
| Yes vs. No | 1.203 | 0.828-1.748 | 0.332 | |||
| Targeted therapy | ||||||
| Yes vs. No | 1.882 | 1.010-3.506 | 0.047 | 1.943 | 0.964-3.914 | 0.063 |
| Tumor length (cm) | ||||||
| ≥5.5 vs. <5.5 | 0.971 | 0.688-1.368 | 0.864 | |||
| Tumor thickness (cm) | ||||||
| ≥1.5 vs. <1.5 | 0.647 | 0.458-0.914 | 0.013 | 0.69 | 0.464-1.026 | 0.067 |
| T stage | ||||||
| T3/T4 vs. T2 | 1.212 | 0.592-2.479 | 0.599 | |||
| N stage | ||||||
| N1/N2/N3 vs. N0 | 0.808 | 0.560-1.168 | 0.257 | |||
| TNM stage | ||||||
| Stage III/Stage IV vs. Stage II | 0.711 | 0.478-1.057 | 0.092 | 0.662 | 0.416-1.051 | 0.080 |
| PNI | ||||||
| ≥47 vs. <47 | 1.188 | 0.846-1.669 | 0.319 | |||
| LMR | ||||||
| ≥10.8 vs. <10.8 | 0.586 | 0.379-0.906 | 0.016 | 0.679 | 0.417-1.105 | 0.119 |
| NLR | ||||||
| ≥1.71 vs. <1.71 | 0.413 | 0.285-0.596 | <0.001 | 0.384 | 0.239-0.619 | <0.001 |
| PLR | ||||||
| ≥136.3 vs. <136.3 | 2.07 | 1.466-2.921 | <0.001 | 3.539 | 2.226-5.626 | <0.001 |
| SII | ||||||
| ≥633.9 vs. <633.9 | 0.772 | 0.538-1.107 | 0.159 | 0.683 | 0.406-1.149 | 0.151 |
RE, radiation esophagitis; OR, odds ratio; 95% CI, 95% confidence interval; RT, radiotherapy; PNI, prognostic nutrition index; LMR, lymphocyte-monocyte ratio; NLR, neutrophil-lymphocyte ratio; PLR, platelet-lymphocyte ratio; SII, systemic immune-inflammation index.