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. 2021 Jun 24;11:682773. doi: 10.3389/fonc.2021.682773

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Copyright © 2021 Lv, Yi, Yan, Chao and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPNS2 mRNA expression in human cancer and noncancerous tissues. (A) SPNS2 expression levels in tumor and adjacent noncancerous tissue from TCGA database. Comparison of SPNS2 expression in tumors and corresponding normal tissues in different types of cancer, which were displayed in gray columns when normal data are available. (Red indicates tumor samples; blue indicates noncancerous samples; purple indicates tumor samples with metastasis; The number of samples in each group is represented in parentheses). ACC, Adrenocortical carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangio carcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSC, Head and Neck squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach adenocarcinoma; TGCT, Testicular Germ Cell Tumors; THCA, Thyroid carcinoma; THYM, Thymoma; UCEC, Uterine Corpus Endometrial Carcinoma; UCS, Uterine Carcinosarcoma; UVM, Uveal Melanoma. (B–F) Human SPNS2 mRNA expression in CRC, adjacent noncancerous tissue and colon adenoma (including low-grade dysplasia and high-grade dysplasia) from various GEO datasets. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05.