TABLE 1.

Comparison between different studies focusing on the cell type tropism of SARS-CoV-2.

Publication	Organoid protocol and age upon infection	Viral strain, time of exposure and MOI	Infection				Viral production
			NSCs	Neurons	Astrocytes	Choroid plexus	NSCs	Neurons	Astrocytes	Choroid plexus
Jacob et al. (2020)	Cortical, age not reported	SARS-CoV-2 USA-WA1/2020, 8 h, MOI 0.1–0.05	N/A	+	+	+	−	−	−	+
Zhang et al. (2020)	Cerebral, Day 35	N/A, 72 h, N/A	+	+	N/A	N/A	+	N/A	N/A	N/A
Ramani et al. (2020)	Cerebral, Day 15 or 60	SARS-CoV-2 NRW-42, 2 days, MOI 1.8 × 10−4 for day 15, 8.8 × 1005 for day 60	−	+	N/A	N/A	−	−	N/A	N/A
Mesci et al. (2020)	Cortical, Day 52	SARS-CoV-2 isolated from a patient in Washington State, 1 week, MOI 2.5	+	+	+	N/A	N/A	N/A	N/A	N/A
Song et al. (2020)	Cerebral, Week 9	SARS-CoV-2 isolate USA-WA1/2020, 24 or 96 h, MOI 1	+	+	N/A	N/A	+	+	N/A	N/A
Andrews et al. (2021)	Cortical, Week 5, 10, 16 or 22	SARS-CoV-2 isolate USA-WA1/2020, 2 h, MOI 0.5	+	+	+	N/A	−	N/A	+	N/A

+, stands for positive; −, for negative; N/A, not investigated; MOI, multiplicity of infection.