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. 2021 Jul 8;19:73. doi: 10.1186/s12964-021-00754-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — BAI macrophage subpopulations. a t-SNE plot showing macrophage subpopulations. b Percentage of the subpopulation of macrophages derived from patients with COVID-19 across different conditions. c Expression of marker genes across macrophage subtypes as visualized on t-SNE (upper) and violin plots. d The difference of cytokine expression levels between moderate and severe groups. e Hypoxia scores of macrophages derived from moderate and severe samples. f Hypoxia score enriched in each of macrophage subpopulation, the score of subpopulations were respectively compared to M0. * p < 0.05, ** p < 0.01, *** p < 0.001 (Student’s t test)