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. 2021 Jul 8;27:70. doi: 10.1186/s10020-021-00337-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The expression and function of MEG3 in trophoblast of URSA. a Analysis of RNA expression profile using the GSE14722 data (RNA-seq data of embryonic villi from 11 abortion patients) and GSE9984 data (RNA-seq data of embryonic villi from 12 normal pregnant women). b The expression levels of MEG3 in embryonic villi from URSA patients and normal tissues using qRT-PCR assays. c Compare the expression of MEG3 in villi from URSA patients and PT-U cells (Primary trophoblast of URSA). d Compare the expression of MEG3 in PT-U cells and PT-N cells (normal primary trophoblast cells). e Compare the proliferative capacity of PT-U cells and PT-N cells. f The effect of MEG3 on the implantation capacity of mouse embryo in vitro. g The expression of MEG3 in MEG3 and shRNA-MEG3 transfected mouse embryo using qRT-PCR assays. h Effects of plasmids harboring MEG3 sequence and shRNA-MEG3 on the expression level of MEG3 in PT-U cells using qRT-PCR. i The effects of MEG3 on the proliferative capacity of PT-U cells using CCK-8 assay. **P < 0.01, *P < 0.05