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. 2021 Jul 8;18:155. doi: 10.1186/s12974-021-02204-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Non-cell autonomous microglial activation in the absence of Cdkl5. A Expression of Cdkl5 mRNA in cortex of 3-month-old Cdkl5 +/+ mice (n=3) and microglial cells purified from 3-month-old Cdkl5 +/+ mice (n=3). Data are given as a percentage of Cdkl5 cortical expression. B Example of immunoblot showing Cdkl5 and GAPDH levels in extracts from somatosensory cortex (CTX) of a wild-type Cdkl5 +/+ mouse and from microglial cells (MG) purified from Cdkl5 +/+ mice (n=4). C Quantification of AIF-1-positive cells (on the left) and mean cell body size (on the right) of microglial cells in hippocampal sections of wild-type (+/Y; n=4) and Emx1 KO (-/Y Emx1; n=5) mice. D Quantification of NeuN positive cells in CA1 layer of hippocampal sections of wild-type (+/Y; n=3) and Emx1 KO (-/Y Emx1; n=3) mice. The results in A, C, and D are presented as means ± SEM. * p<0.05; **p< 0.01; ***p<0.001 (two-tailed Student’s t-test)