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. 2021 May 21;49(W1):W304–W316. doi: 10.1093/nar/gkab359

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Performance of the final selected KEA3 libraries and integration methods in recovering the perturbed and drug-targeted kinase(s) from the three benchmarking datasets. (A–C) ROC curves for KinCREEDSupdn, DrugL1000updn, and PTMsigDB.drug, respectively; (D–F) Composite PR curves generated from 5,000 bootstrapped curves for KinCREEDSupdn, DrugL1000updn, and PTMsigDB.drug, respectively; (G–I) The deviation of the cumulative distribution from uniform of the scaled rankings of the ‘true’ kinases for KinCREEDSupdn, DrugL1000updn and PTMsigDB.drug, respectively.