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. Author manuscript; available in PMC: 2021 Oct 14.
Published in final edited form as: Neuron. 2020 Aug 7;108(1):164–179.e7. doi: 10.1016/j.neuron.2020.07.012

Figure 6: A stochastic circadian computation model to explain experimental observations.

Figure 6:

(A) Computational model as the outcome of parameterization of the circadian circuits based on approximated ratios of SCN neurons (53 AVP cells, 27 VIP cells, and 170 non-AVP/non-VIP cells). The AVP:VIP coupling strength was set to 2.5:1. (B) Single-cell trajectories of each cell type. The signals represent relative expression level. Three models representing a wildtype, a VIP-Bmal1−/− (cKO) or an AVP-Bmal1−/− (cKO) SCN are shown. (C) Pairwise MIC scores represent six inter- or intra-class connections and correlations. X axis and Y axis represent the cell classes, and the pairing pattern of the classes is divided by dashed lines. (D) Proposed mechanism of the differential roles of VIP and AVP neurons in the SCN. Entrainment occurs under daylight and switches to free-running under constant darkness. Green color and minus signs indicate the excision of Bmal1 and ablation of autonomous circadian rhythms, while red color and plus signs indicate intact cells.