Table 6.
The effect of glutapyrone on Psma3, Psmb5 and Psmc6 gene expression in the kidney and blood
| Glutapyrone (mg/kg) | Kidney fold difference (SEM range) | Blood fold difference (SEM range) | |
|---|---|---|---|
| Psma3 | Control | 1.00 (0.93–1.07) | 1.00 (0.87–1.14) |
| 0.05 | 1.10 (0.95–1.26) | 1.49 (1.27–1.74) | |
| 0.50 | 1.21 (1.05–1.39) | 0.99 (0.86–1.14) | |
| Psmb5 | Control | 1.00 (0.93–1.08) | 1.00 (0.84–1.18) |
| 0.05 | 1.40 (1.26–1.55) | 2.04 (1.94–2.14)* | |
| 0.50 | 1.73 (1.49–2.01)** | 1.66 (1.56–1.77) | |
| Psmc6 | Control | 1.00 (0.94–1.07) | 1.00 (0.90–1.12) |
| 0.05 | 1.46 (1.28–1.66)* | 1.30 (1.19–1.42) | |
| 0.50 | 1.59 (1.46–1.73)** | 0.96 (0.84–1.11) |
*P<0.05 and **P<0.01 compared to control