Table 7.
The effect of AV-153-Na on Psma3, Psmb5, Psmc6 and Psma6 gene expression in the kidney and liver
| AV-153-Na (mg/kg) | Kidneys fold difference (SEM range) | Liver fold difference (SEM range) | |
|---|---|---|---|
| Psma3 | Control | 1.00 (0.97–1.03) | 1.00 (0.95–1.05) |
| 0.05 | 1.28 (1.21–1.35)* | 0.94 (0.82–1.08) | |
| 0.50 | 1.28 (1.12–1.46)* | 1.23 (1.19–1.26) | |
| Psmb5 | Control | 1.00 (0.99–1.02) | 1.00 (0.94–1.04) |
| 0.05 | 1.64 (1.51–1.78)*** | 0.79 (0.71–0.87)* | |
| 0.50 | 1.68 (1.47–1.91)*** | 1.09 (1.08–1.11) | |
| Psmc6 | Control | 1.00 (0.97–1.03) | 1.00 (0.92–1.09) |
| 0.05 | 1.39 (1.29–1.51)** | 1.19 (1.07–1.33) | |
| 0.50 | 1.47 (1.30–1.66)** | 1.61 (1.59–1.62)* | |
| Psma6 | Control | 1.00 (0.92–1.08) | 1.00 (0.94–1.06) |
| 0.05 | 2.00 (1.78–2.25)*** | 1.49 (1.32–1.68)** | |
| 0.50 | 2.17 (1.87–2.52)*** | 1.91 (1.86–1.95)*** |
*P<0.05, **P<0.01, and ***P<0.001 compared to control