Table 8.

The effect of AV-153-Ca on Psma3, Psmb5, Psmc6 and Psma6 gene expression in the kidney and liver

	AV-153-Ca (mg/kg)	Kidney fold difference (SEM range)	Liver fold difference (SEM range)
Psma3	Control	1.00 (0.97–1.03)	1.00 (0.95–1.05)
	0.05	0.89 (0.76–1.03)	0.96 (0.94–0.99)
	0.50	1.00 (0.92–1.09)	0.89 (0.81–0.97)
Psmb5	Control	1.00 (0.99–1.02)	1.00 (0.94–1.04)
	0.05	0.62 (0.55–0.71)**	1.05 (1.03–1.08)
	0.50	0.85 (0.75–0.95)	0.82 (0.71–0.95)
Psmc6	Control	1.00 (0.97–1.03)	1.00 (0.92–1.09)
	0.05	0.85 (0.77–0.93)	0.89 (0.86–0.93)
	0.50	0.90 (0.84–0.96)	0.96 (0.88–1.05)
Psma6	Control	1.00 (0.92–1.08)	1.00 (0.94–1.06)
	0.05	1.03 (0.96–1.11)	0.87 (0.82–0.93)
	0.50	0.98 (0.89–1.07)	1.35 (1.22–1.48)*

*P<0.05 and **P<0.01 compared to control