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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Nat Med. 2021 Mar 18;27(4):677–687. doi: 10.1038/s41591-021-01284-y

Extended Data Fig. 2 ∣. Off-target analysis of HBA1-specific sg5.

Extended Data Fig. 2 ∣

a, Summary of rhAmpSeq targeted sequencing results at on-target and 40 most highly predicted off-target sites by COSMID for HBA1 sg5. Values are indel frequency for RNP treatment after subtraction of indel frequency for Mock treatment at each locus for each experimental replicate. N = 3 biologically independent HSPC donors, though not all values are displayed since some were <0.01% after subtraction of Mock indel frequencies. Bars represent median. b, List of genomic coordinates for forty most highly predicted off-target sites by COSMID for HBA1 sg5.