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. 2021 Jun 24;12:674079. doi: 10.3389/fimmu.2021.674079

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Copyright © 2021 Bongers, Chen, van Grinsven, van Staveren, Hassani, Spijkerman, Hesselink, Lo Tam Loi, van Aalst, Leijte, Kox, Pickkers, Hietbrink, Leenen, Koenderman and Vrisekoop

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal data from multitrauma patients. Representative FACS examples of CD16/CD62L plot of blood from a multitrauma patient. From left to right: at admission (day 0), 3 days, 6 days, 10 days and 15 days after admission to the hospital (A). Kinetics of cell counts over time of all circulating neutrophils (upper left panel), CD16^low neutrophils (upper right panel), mature CD16^high/CD62L^high neutrophils (lower left panel) and CD62L^low neutrophils (lower right panel). Data from a unique individual is represented by a unique color. A line is plotted through the medians of every time point. In the upper left panel, the normal range of blood counts for neutrophils is marked by a green area ranging from 1,5 to 9*10⁶ cells/mL (B).