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. 2021 Jun 24;12:674079. doi: 10.3389/fimmu.2021.674079

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Copyright © 2021 Bongers, Chen, van Grinsven, van Staveren, Hassani, Spijkerman, Hesselink, Lo Tam Loi, van Aalst, Leijte, Kox, Pickkers, Hietbrink, Leenen, Koenderman and Vrisekoop

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COVID-19 patients pre- and post-ICU. Representative FACS examples of CD16/CD62L plot of blood from a hospitalized COVID-19 patient before admission to the ICU (left panel) and from the same patient post-ICU with corresponding nuclear morphology of the subsets (right panel) (A). Cell counts of CD16^low neutrophils (left panel) and CD62L^low neutrophils (right panel) in healthy control (HC) blood (n=23) and in blood from COVID-19 patients pre-ICU (n=9) and post-ICU (n=41) (B). Lines are means with SD. A one-way ANOVA analysis (unpaired) with a post-hoc Dunnett’s multiple comparisons test was used to test significance. Significance is displayed in graphs as ns, not significant, P**** <0,0001.