Table 3.
The prescribed antifungal prophylaxes of pediatrics with hematological diseases.
| Disease | Antifungal prophylaxis | IFD (n = 4) | Non-IFD (n = 45) | Total (n = 49) | P value |
|---|---|---|---|---|---|
| ALL | |||||
| Itraconazole | 1 (50.0) | 4 (100) | 5 (83.3) | 0.333 | |
| Posaconazole | 1 (50.0) | 0 | 1 (16.7) | ||
| AML | |||||
| Itraconazole | 1 (100) | 8 (61.5) | 9 (64.3) | 0.741 | |
| Fluconazole | 0 | 2 (15.4) | 2 (14.3) | ||
| Posaconazole | 0 | 3 (23.1) | 3 (21.4) | ||
| Relapsed leukemia | N/A | ||||
| Itraconazole | 0 | 8 (53.3) | 8 (53.3) | ||
| Fluconazole | 0 | 3 (20.0) | 3 (20.0) | ||
| Posaconazole | 0 | 4 (26.7) | 4 (26.7) | ||
| SAA | |||||
| Itraconazole | 0 | 3 (23.1) | 3 (21.4) | 0.040 | |
| Fluconazole | 0 | 9 (69.2) | 9 (64.3) | ||
| Posaconazole | 1 (100) | 1 (7.7) | 2 (14.3) |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; IFD, invasive fungal disease; N/A, not applicable; SAA, severe aplastic anemia.