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(A) Overall survival (OS), (B) disease-free survival (DFI), (C) locoregional failure–free interval (LFFI), and (D) distant metastasis–free interval (DMFI) in 246 patients randomly assigned to preoperative chemoradiotherapy (CRT; 119 patients) or immediate surgery (127 patients) according to intention-to-treat analysis. Tick marks indicate censored observations. HR, hazard ratio.
