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Zuranolone exhibited PAM activity at all GABAA receptors tested.
| Receptor Type | EC50 (nM) | Emax (%) | Cell type |
|---|---|---|---|
| α4β3δ | 118 | 556 | CHO |
| α1β2γ2 | 430 | 1037 | Ltk |
| α2β2γ2 | 184 | 1343 | Ltk |
| α1β3γ2 | 390 | 684 | HEK293 |
| α2β3γ2 | 516 | 1045 | HEK293 |
| α3β3γ2 | 293 | 291 | HEK293 |
| α5β3γ2 | 298 | 534 | HEK293 |
| α1β1γ2 | 1260 | 1435 | Xenopus oocytes |
| α6β3δ | 780 | 1590 | Xenopus oocytes |
