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. 2021 Jun 24;11:620912. doi: 10.3389/fonc.2021.620912

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Copyright © 2021 Li, Chen, Ran, Huang, Sun, Zeng, Zhang, Zhang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of TARBP2 in HCC is associated with poor prognosis. (A) The mRNA expression of TARBP2 was consistently downregulated across HCC cell lines compared with the normal liver L02 cells. (B) Downregulation of TARBP2 mRNA was confirmed in 52 pairs of patient-derived HCC tumors and adjacent tissues. (C) HCC patients with a relatively lower mRNA expression of TARBP2 had a worse three-year OS. (D) The protein expression of TARBP2 was higher in adjacent tissues relative to tumors. (E) The mRNA expression of TARBP2 in patient-derived blood samples was lower relative to healthy controls. (F) TARBP2 mRNA expression in the blood distinguished HCC patients from healthy controls. OS, overall survival; IHC, immunohistochemistry; AUC, area under curve; CI, confidence interval; *p-value < 0.05; **p-value < 0.01; ****p-value < 0.0001.